Product Name	CA I
Chinese Name	碳酸酐酶1抗体
Alias	Carbonic anhydrase I; Carbonic Anhydrase-I; Carbonic Anhydrase 1; Carbonic anhydrase1; Carbonic anhydrase-1; JW0122; CA 1; CA1; CA I; CA-1; CAI; CAN; Car 1; Car1; Carbonate dehydratase I; Carbonic anhydrase 1; Carbonic anhydrase B; Carbonic dehydratase; ECK0125; yadF; CAH1_MOUSE.
Research Area	Cardiovascular  Cell biology  immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	29kDa
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CA I: 161-261/261
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature. [provided by RefSeq, Sep 2009] Function: Reversible hydration of carbon dioxide. Subcellular Location: Cytoplasm. Similarity: Belongs to the alpha-carbonic anhydrase family. SWISS: P00915 Gene ID: 759 Database links: Entrez Gene: 759 Human Entrez Gene: 12346 Mouse Entrez Gene: 310218 Rat Omim: 114800 Human SwissProt: P00915 Human SwissProt: P13634 Mouse SwissProt: B0BNN3 Rat Unigene: 23118 Human Unigene: 273195 Mouse Unigene: 6854 Rat CA1(Carbonic anhydrase1)是红细胞的主要蛋白质成分之一,是一种重要的锌酶，对血液及组织起到维持酸碱平衡的作用，协助体内组织排除二氧化碳，碳酸酐酶I参与呼吸、钙化、酸碱平衡、骨吸收和各种体液形成的生理过程。
Product Picture	Sample: Spleen (Mouse) Lysate at 40 ug Primary: Anti- CA I (SL1592R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 29 kD Observed band size: 29 kD Paraformaldehyde-fixed, paraffin embedded (mouse spleen); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CA I) Polyclonal Antibody, Unconjugated (SL1592R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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