Product Name	Mannan Binding Lectin
Chinese Name	甘露聚糖结合凝集素抗体
Alias	Mbl2; L-MBP; MBL; MBL-C; MBP-C; COLEC 1; COLEC1; HSMBPC; Mannan binding protein; Mannose binding lectin (protein C) 2 soluble; Mannose binding lectin 2 soluble; Mannose binding lectin; Mannose binding lectin protein C2 soluble opsonic defect; Mannose binding protein; Mannose binding protein C; Mannose binding protein C precursor; MBL 2; MBP 1; MBP; MBP C; MBP1; MBPC; MGC116832; MGC116833; Opsonic defect; protein C ; Soluble mannose binding lectin; MBL2_HUMAN.
literatures	Specific References  (1)     |     SL1582R has been referenced in 1 publications. [IF=3.118] Peng X et al. Interaction of mannose binding lectin and other pattern recognition receptors in human corneal epithelial cells during Aspergillus fumigatus infection. Int Immunopharmacol. 2018 Oct;63:161-169.  WB&IHF ;  Mouse&Human.   PubMed:30096599
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rabbit, )
Applications	ELISA=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	26kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MBL: 31-130/248
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]. Function: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Subunit: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity. Subcellular Location: Secreted. Tissue Specificity: Plasma protein produced mainly in the liver. Similarity: Contains 1 C-type lectin domain. Contains 1 collagen-like domain. SWISS: P11226 Gene ID: 4153 Database links: Entrez Gene: 4153 Human Entrez Gene: 17195 Mouse Omim: 154545 Human SwissProt: P11226 Human SwissProt: P41317 Mouse Unigene: 499674 Human Unigene: 30045 Mouse MBL （mannan binding lectin）甘露聚糖结合凝集素，MBL是一种兼有调理素和直接激活补体功能的免疫分子，参与构成抗感染的第一道防线。MBL2在发生急性期反应时由肝脏分泌，并参与天然免疫防御。凝集素配体可以存在于各种各样的微生物中，两者结合后可以导致调理作用并激活补体系统。

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