Product Name	RRM1
Chinese Name	核糖核苷酸还原酶1抗体
Alias	ribonucleotide reductase R1 mRNA; R1; Ribonucleoside diphosphate reductase large subunit ; Ribonucleoside diphosphate reductase M1 chain; Ribonucleoside diphosphate reductase subunit M1; Ribonucleotide reductase large chain; Ribonucleotide reductase large subunit; Ribonucleotide reductase M1 polypeptide; Ribonucleotide reductase R1 subunit; RIR 1; RIR1; RR 1; RR1; RRM 1; RIR1_HUMAN.
Research Area	Cell biology  Chromatin and nuclear signals  Kinases and Phosphatases  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	90kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RRM1: 733-778/792
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	RRM1 (Ribonucleotide reductase M1 polypeptide) is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer to treatment. Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Subunit: Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B. Subcellular Location: Cytoplasm. Similarity: Belongs to the ribonucleoside diphosphate reductase large chain family. Contains 1 ATP-cone domain. SWISS: P23921 Gene ID: 6240 Database links: Entrez Gene: 6240 Human Entrez Gene: 20133 Mouse Entrez Gene: 685579 Rat Omim: 180410 Human SwissProt: P23921 Human SwissProt: P07742 Mouse Unigene: 445705 Human Unigene: 197486 Mouse Unigene: 162454 Rat 核糖核苷酸还原酶普遍存在于很多生物中,是生物体内唯一的催化4种核糖核苷酸还原并生成相应的脱氧核糖核苷酸的酶. 核糖核苷酸还原酶1也是DNA合成和修复的关键酶和限速酶,对细胞的增殖和分化起着调控作用。

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