Product Name	Reelin
Chinese Name	络丝蛋白抗体
Alias	Reelin; Reeler; RELN; RL; LIS2; PRO1598; RELN_HUMAN.
Research Area	Cell biology  immunology  Neurobiology  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Horse, Guinea Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	400-450;300;180-kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RELN: 3345-3458/3458
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in “reeler” mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1 in a signaling pathway that controls cell positioning in the developing brain and is also thought to be a direct effector of the neurotrophin BDNF. Function: This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. Subcellular Location: Secreted Tissue Specificity: High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level). Post-translational modifications: N-glycosylated; more than 90% of the glycans are sialylated. Similarity: Belongs to the ALB/AFP/VDB family. Contains 3 albumin domains. SWISS: P78509 Gene ID: 5649 Database links: Entrez Gene: 5649 Human Entrez Gene: 19699 Mouse Entrez Gene: 24718 Rat Omim: 600514 Human SwissProt: P78509 Human SwissProt: Q60841 Mouse SwissProt: P58751 Rat Unigene: 655654 Human Unigene: 425236 Mouse Unigene: 98353 Rat Reelin蛋白作用目前还在进一步研究中，但有学者认为它与β-Amyloid 的神经缠结有相对应的作用。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Reelin) Polyclonal Antibody, Unconjugated (SL1560R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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