Product Name	OAS2
Chinese Name	2'-5'-寡腺苷酸合成酶2抗体
Alias	(2-5'')oligo(A) synthase 2; (2-5')oligo(A) synthetase 2; 2''-5''-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2; 2-5A synthetase 2; MGC78578; OAS2; OAS2_HUMAN; p69 OAS / p71 OAS; p69OAS / p71OAS.
Research Area	Cell biology  immunology  Chromatin and nuclear signals  Mitochondrion
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Dog, Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	82kDa
Cellular localization	The nucleus cytoplasmic Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human OAS2: 401-500/719
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Function: Interferon-induced, dsRNA-activated antiviral enzymewhich plays a critical role in cellular innate antiviral response.In addition, it may also play a role in other cellular processessuch as apoptosis, cell growth, differentiation and generegulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form ofribonuclease L (RNase L) leading to its dimerization and subsequentactivation. Activation of RNase L leads to degradation of cellularas well as viral RNA, resulting in the inhibition of proteinsynthesis, thus terminating viral replication. Can mediate theantiviral effect via the classical RNase L-dependent pathway or analternative antiviral pathway independent of RNase L.[CATALYTIC ACTIVITY] 3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate. Subunit: Homodimer. Subcellular Location: Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum.Note=Associated with different subcellular fractions such asmitochondrial, nuclear, and rough/smooth microsomal fractions. Post-translational modifications: Myristoylation is not essential for its activity. Glycosylated. Glycosylation is essential for its activity. Similarity: Belongs to the 2-5A synthase family. SWISS: P29728 Gene ID: 4939 Database links: Entrez Gene: 4939 Human Entrez Gene: 246728 Mouse Omim: 603350 Human SwissProt: P29728 Human SwissProt: E9Q9A9 Mouse Unigene: 414332 Human Unigene: 260926 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (OAS2) Polyclonal Antibody, Unconjugated (SL15588R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (OAS2) Polyclonal Antibody, Unconjugated (SL15588R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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