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Product Name MPP4 Chinese Name MPP4蛋白抗体 Alias MAGUK p55 subfamily member 4; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein; Discs large homolog 6; MPP4_HUMAN; ALS2CR5; DLG6; DLG6; Membrane palmitoylated protein 4; Membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4); OTTHUMP00000205933; OTTHUMP00000209441; OTTHUMP00000209442; OTTHUMP00000209443. Research Area Cell biology immunology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 73kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MPP4: 331-430/637 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Function:
May play a role in retinal photoreceptors development (By similarity).
Subunit:
Interacts with MPDZ. May interact with GRIA2 (By similarity). Forms a complex with CRB1 and MPP5. Interacts with FASLG.
Subcellular Location:
Cytoplasm. Note=Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ).
Tissue Specificity:
Expressed in the retina (at protein level). Highly expressed in the retina. Lower amounts are detected in brain, testis, ARPE-19, RPE/choroid and fetal eye. Isoform 5 is retina-specific.
Similarity:
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 2 L27 domains.
Contains 1 PDZ (DHR) domain.
Contains 1 SH3 domain.
SWISS:
Q96JB8
Gene ID:
58538
Database links:Entrez Gene: 58538 Human
Entrez Gene: 227157 Mouse
Omim: 606575 Human
SwissProt: Q96JB8 Human
SwissProt: Q6P7F1 Mouse
Unigene: 63085 Human
Unigene: 474049 Mouse
Unigene: 163075 Rat
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