Product Name	MPP4
Chinese Name	MPP4蛋白抗体
Alias	MAGUK p55 subfamily member 4; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein; Discs large homolog 6; MPP4_HUMAN; ALS2CR5; DLG6; DLG6; Membrane palmitoylated protein 4; Membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4); OTTHUMP00000205933; OTTHUMP00000209441; OTTHUMP00000209442; OTTHUMP00000209443.
Research Area	Cell biology  immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	73kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MPP4: 331-430/637
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. Function: May play a role in retinal photoreceptors development (By similarity). Subunit: Interacts with MPDZ. May interact with GRIA2 (By similarity). Forms a complex with CRB1 and MPP5. Interacts with FASLG. Subcellular Location: Cytoplasm. Note=Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ). Tissue Specificity: Expressed in the retina (at protein level). Highly expressed in the retina. Lower amounts are detected in brain, testis, ARPE-19, RPE/choroid and fetal eye. Isoform 5 is retina-specific. Similarity: Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 2 L27 domains. Contains 1 PDZ (DHR) domain. Contains 1 SH3 domain. SWISS: Q96JB8 Gene ID: 58538 Database links: Entrez Gene: 58538 Human Entrez Gene: 227157 Mouse Entrez Gene: 58808 Rat Omim: 606575 Human SwissProt: Q96JB8 Human SwissProt: Q6P7F1 Mouse SwissProt: Q9QYH1 Rat Unigene: 63085 Human Unigene: 474049 Mouse Unigene: 163075 Rat

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