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Product Name GPR114 Chinese Name G protein-coupled receptorGPR114蛋白抗体 Alias G protein coupled receptor 114; G-protein coupled receptor PGR27; GP114; GP114_HUMAN; GPR114; PGR27; Probable G-protein coupled receptor 114; UNQ2524/PRO6017. Research Area Cell biology immunology Neurobiology G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Human, Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 57kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GPR114: 1-100/523 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR114 (G protein-coupled receptor 114), also known as G-protein coupled receptor PGR27, is a 528 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and LN-TM7 subfamily. Containing one GPS domain and mapping to human chromosome 16, GPR114 functions as an orphan receptor. Chromosome 16 encodes over 900 genes, comprises nearly 3% of the human genome and is associated with both Rubinstein-Taybi syndrome and Crohn's disease.
Function:
Orphan receptor.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
SWISS:
Q8IZF4
Gene ID:
221188
Database links:Entrez Gene: 221188 Human
SwissProt: Q8IZF4 Human
Unigene: 187884 Human
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