Product Name	GPCR TGR7
Chinese Name	G protein-coupled receptorTGR7蛋白抗体
Alias	Beta-alanine receptor; G-protein coupled receptor TGR7; Mas-related G-protein coupled receptor member D; MRGD; MRGPRD; MRGRD; TGR7; MRGRD_HUMAN.
Research Area	Cell biology  immunology  Neurobiology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GPCR TGR7: 101-200/321 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Mas-related G protein-coupled receptors are sensory neuron-specific G protein-coupled receptors that are usually involved in the development and function of nociceptive neurons and may also regulate the sensation or modulation of pain. MRGD (MAS-related GPR, member D), also known as MRGPRD or TGR7, is a 321 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor 1 family and the Mas subfamily. MRGD is suggested to function specifically as a receptor for beta-alanine, a naturally occurring beta amino acid. Beta-alanine induces Ca2+ influx and decreases forskolin-stimulated cAMP production in cells expressing MRGD. Neurons of outer epidermis that express MRGD act as nociceptors in which they respond indirectly to external stimuli by detecting ATP release in the skin. MRGD is encoded by a gene located on human chromosome 11q13.2. Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). Subcellular Location: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine. Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. SWISS: Q8TDS7 Gene ID: 116512 Database links: Entrez Gene: 116512 Human Entrez Gene: 211578 Mouse Entrez Gene: 293648 Rat SwissProt: Q8TDS7 Human SwissProt: Q91ZB8 Mouse SwissProt: Q7TN41 Rat Unigene: 527802 Human Unigene: 370299 Mouse Unigene: 162482 Rat

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