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Product Name GPCR MRGX2 Chinese Name G protein-coupled receptorMRGX2蛋白抗体 Alias Mas-related G-protein coupled receptor member X2; MRGPRX2; MRGX2; MRGX2_HUMAN. Research Area Cell biology immunology Neurobiology G protein-coupled receptor The new supersedes the old G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 37kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GPCR MRGX2 : 1-100/330 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the development and function of nociceptive neurons and may also regulate the sensation or modulation of pain. MRGPRX2, is a 330 amino acid multi-pass membrane protein that functions as an orphan receptor and, like MRGX, is thought to be involved in the function of nociceptive neurons. Expressed in the central nervous system with highest expression in dorsal root ganglia, MRGX2 may also be involved in cortistatin function, possibly playing a role in sleep regulation and cortical function.
Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
Similarity:
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
SWISS:
Q96LB1
Gene ID:
117194
Database links:Entrez Gene: 117194 Human
Omim: 607228 Human
SwissProt: Q96LB1 Human
Unigene: 350566 Human
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