Product Name	GPCR LGR7
Chinese Name	G protein-coupled receptorLGR7蛋白抗体
Alias	Gm1018; Leucine rich repeat containing G protein coupled receptor 7;LGR7; LGR7.1; LGR7.10; LGR7.2; MGC138347; MGC142177; Relaxin family peptide receptor 1; Relaxin receptor 1; Relaxin/insulin like family peptide receptor 1; RXFP 1; RXFP1; RXFP1; RXFP1_HUMAN; RXFPR1.
literatures	Specific References  (1)     |     SL15368R has been referenced in 1 publications. [IF=6.208] Anqi Sun. et al. Serelaxin Alleviates Fibrosis in Thyroid-Associated Ophthalmopathy via the Notch Pathway. INT J MOL SCI. 2023 Jan;24(9):8356  IHC,IF ;  Human.   PubMed:37176063
Research Area	Cell biology  immunology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	87kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GPCR LGR7: 301-400/757 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Function: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen. Similarity: Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 9 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. SWISS: Q9HBX9 Gene ID: 59350 Database links: Entrez Gene: 59350 Human Entrez Gene: 381489 Mouse Entrez Gene: 295144 Rat Omim: 606654 Human SwissProt: Q9HBX9 Human SwissProt: Q6R6I7 Mouse SwissProt: Q6R6I6 Rat Unigene: 591686 Human Unigene: 331086 Mouse Unigene: 109230 Rat

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