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Product Name Persephin Chinese Name PSP抗体 Alias PSPN_HUMAN; PSP. literatures Specific References (1) | SL1518R has been referenced in 1 publications.[IF=5.076] Asally R et al.The Expression and Cellular Localisation of Neurotrophin and Neural Guidance Molecules in Peritoneal Ectopic Lesions.Mol Neurobiol. 2018 Sep 25 IHC ; Rat.Research Area Developmental biology Neurobiology Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 14kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Persephin: 51-156/156 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma. [provided by RefSeq, Aug 2016]
Function:
Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
Subunit:
Homodimer; disulfide-linked.
Subcellular Location:
Secreted.
Similarity:
Belongs to the TGF-beta family. GDNF subfamily.
SWISS:
O60542
Gene ID:
5623
Database links:Entrez Gene: 5623 Human
Omim: 602921 Human
SwissProt: O60542 Human
Unigene: 248159 Human
Neurobiology相关蛋白(Neurobiology)
PSP是TGF-β家族的一个新亚族,该亚族还有其他三个成员:Neurturin(NTN)、GDNF和Artemin(ART),它们均不同程度地对多巴胺神经元、脊髓前角运动神经元、背根神经节、颈上神经节以及肾等非神经元细胞都具有生长促进作用。研究表明胶质细胞系源性神经营养因子,主要用于PD的研究。
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