Product Name	CNTF Receptor alpha
Chinese Name	睫状神经营养因子受体α抗体
Alias	CNTFR Alpha; Ciliary neurotrophic factor receptor alpha; CNTFR Alpha; CNTFR; Ciliary neurotrophic factor receptor alpha; Ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR Alpha; CNTFR; CNTFR-alpha; CNTFR.  CNTFR α; CNTFRα.
literatures	Specific References  (1)     |     SL1516R has been referenced in 1 publications. [IF=3.53] Schwieger J, Warnecke A, Lenarz T, Esser K-H, Scheper V (2015) Neuronal Survival, Morphology and Outgrowth of Spiral Ganglion Neurons Using a Defined Growth Factor Combination. PLoS ONE 10(8): e0133680.  Rat.   PubMed:26263175
Research Area	immunology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CNTFR Alpha: 151-160/372
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]. Function: Binds to CNTF. The alpha subunit provides the receptor specificity. Subunit: Heterotrimer of the alpha subunit, LIFR and IL6ST. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Nervous system and skeletal muscle. Similarity: Belongs to the type I cytokine receptor family. Type 3 subfamily. Contains 2 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SWISS: P26992 Gene ID: 1271 Database links: Entrez Gene: 442941 Dog Entrez Gene: 1271 Human Entrez Gene: 12804 Mouse Entrez Gene: 313173 Rat Omim: 118946 Human SwissProt: Q71DR4 Dog SwissProt: P26992 Human SwissProt: O88507 Mouse SwissProt: Q08406 Rat Unigene: 129966 Human Unigene: 425178 Mouse Unigene: 55036 Rat Neurobiology相关蛋白（Neurobiology） CNTFRα是CNTF的特异性Binding protein。在周围神经损伤后CNTF与其受体有其特异的变化模式及调节机制，对神经损伤后的再生有重要作用。

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