Product Name	GnRHR
Chinese Name	促性腺激素释放激素受体抗体
Alias	Gonadotropin-releasing hormone receptor; GH1; Lhrhr; GnRH receptor; gnrh-r; GnRHR; GNRHR1; Gonadotropin releasing hormone receptor; GRHR; leutinizing-releasing hormone receptor; lh-rh; LHRHR; LRHR; luteinizing hormone releasing hormone receptor; GNRHR_HUMAN
literatures	Specific References  (4)     |     SL1464R has been referenced in 4 publications. [IF=4.736] Lu Xiaosheng. et al. Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control. ENDOCRINOLOGY. 2022 Apr;:  IHC ;  Mouse.   PubMed:10.1210/endocr/bqac048 [IF=3.34] López-Doval, S., R. Salgado, and A. Lafuente. "The expression of several reproductive hormone receptors can be modified by perfluorooctane sulfonate (PFOS) in adult male rats." Chemosphere 155 (2016): 488-497.  Rat.   PubMed:27151425 [IF=3.14] Liu, Te, et al. "Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats." Reproductive Toxicology (2014).  IHC-P ;  Rat.   PubMed:24675100 [IF=1.39] Xiao, Liu, et al. "Distribution patterns and developmental changes of GnRH and GnRHR-immunopositive cells in the pituitary of Ji Ning gray goats." Pakistan Veterinary Journal 34.1 (2014): 116-119.  IHC-P ;  Goat.   PubMed:ISBN:0253-8318
Research Area	Signal transduction  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GnRHR: 201-328/328 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Gonadotropin Releasing Hormone (GnRH) is down-regulated by hCG and believed to be an autocrine factor that regulates the ovary. The Gonadotropin Releasing Hormone Receptor (GnRHR) is synthesized in the pituitary gland. Activin A has been shown to stimulate the synthesis of GnRHR, illustrating a possible mechanism for the modulation of gonadotropin responsiveness to GnRH. Function: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Pituitary, ovary, testis, breast and prostate but not in liver and spleen. DISEASE: Hypogonadotropic hypogonadism 7 with or without anosmia (HH7) [MIM:146110]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations affecting the gene represented in this entry. Fertile eunuch syndrome (FEUNS) [MIM:228300]: Mild phenotypic form of HH going with the presence of normal testicular size and some degree of spermatogenesis. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P30968 Gene ID: 2798 Database links: Entrez Gene: 403718 Dog Entrez Gene: 2798 Human Entrez Gene: 397515 Pig Entrez Gene: 100009509 Rabbit Omim: 138850 Human SwissProt: Q9MZI6 Dog SwissProt: P30968 Human SwissProt: P49922 Pig Unigene: 407587 Human 信号传导（Signaling Intermediates） Grb2是生长因子受体Binding protein2,又称Ash蛋白。该蛋白参与细胞内各种受体激活后的下游调节。能够直接与激活的表皮生长因子受体磷酸化的酪氨酸结合,参与EGF受体介导的Signal transduction, 属SH蛋白.
Product Picture	Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: A549 (Human) Cell Lysate at 30 ug Primary: Anti-GnRHR (SL1464R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 62-70 kD Observed band size: 63 kD Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-GnRHR Polyclonal Antibody, Unconjugated(SL1464R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat brain tissue;4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-GnRHR Polyclonal Antibody, Unconjugated(SL1464R) 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(SL0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C. DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei

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