Product Name	ERLEC1
Chinese Name	内质网凝集素1抗体
Alias	C2orf30; CL24936; CL2508; endoplasmic reticulum lectin 1; ER lectin; erlectin 1; RP23 20N14.5; ERLEC_HUMAN; XTP3 B; XTP3 transactivated gene B protein; XTP3 transactivated protein B; XTP3B; XTP3TPB.
Research Area	Cell biology  Transporter  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ERLEC1: 391-483/483
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011] Function: ERLEC1 is a probable lectin that binds selectively to improperly folded lumenal proteins. ERLEC1 may function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. Subunit: May form a complex with OS9, HSPA5, SYVN1, and SEL1L with which it interacts directly. Interacts (via PRKCSH 2 domain) with KREMEN2 (when glycosylated). Interacts with HSPA5. Subcellular Location: Endoplasmic reticulum lumen. Post-translational modifications: Isoform 1 and isoform 2 are N-glycosylated. Similarity: Contains 2 PRKCSH domains. SWISS: Q96DZ1 Gene ID: 27248 Database links: Entrez Gene: 27248 Human Omim: 611229 Human SwissProt: Q96DZ1 Human Unigene: 438336 Human

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