Product Name	EFHD2
Chinese Name	EFHD2蛋白抗体
Alias	EF hand domain containing protein 2; EF hand domain family, member D2; EF-hand domain-containing protein D2; EFHD 2; EFHD2; EFHD2_HUMAN; RP3-467K16.3; Swiprosin 1; Swiprosin-1; SWS1.
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EFHD2: 51-150/240
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	EFHD2 is a 240 amino acid protein that regulates spontaneous apoptosis through the regulation of Bcl-xS abundance. Localized to membrane raft, Swiprosin-1 is expressed in lymphocytes and contains two EF-hand domains. The gene encoding Swiprosin-1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. Function: May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Subcellular Location: Membrane raft. In immature B-cell line WEHI231. Tissue Specificity: Found in lymphocytes; preferentially expressed in CD8+ cells. Similarity: Contains 2 EF-hand domains. SWISS: Q96C19 Gene ID: 79180 Database links: Entrez Gene: 79180 Human Entrez Gene: 27984 Mouse Entrez Gene: 298609 Rat SwissProt: Q96C19 Human SwissProt: Q9D8Y0 Mouse SwissProt: Q4FZY0 Rat Unigene: 465374 Human Unigene: 395598 Mouse Unigene: 92713 Rat
Product Picture	Protein:spleen(mouse) lysate at 40ug; Primary: rabbit Anti-EFHD2 (SL14520R) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1: 5000; Predicted band size: 27 kD Observed band size: 27 kD

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