Product Name	EFCAB6
Chinese Name	EFCAB6蛋白抗体
Alias	DJBP; CAP binding protein complex interacting protein 1; DJ1 binding protein; DJBP; EFCB6_HUMAN; EF hand calcium binding domain 6; FLJ23588.
Research Area	Cell biology  Signal transduction  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	173kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EFCAB6: 1401-1501/1501
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Function: Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ1 antagonizes this inhibition by abrogation of this complex. Six named isoforms produced by alternative splicing. Subunit: Binds PARK7. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR. Subcellular Location: Nucleus. Tissue Specificity: Specifically expressed in the testis. Similarity: Contains 17 EF-hand domains. SWISS: Q5THR3 Gene ID: 64800 Database links: Entrez Gene: 64800 Human SwissProt: Q5THR3 Human Unigene: 658996 Human

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