Product Name	EFCAB4A
Chinese Name	EFCAB4A蛋白抗体
Alias	EF-CAB4A; Calcium release-activated calcium channel regulator 2B; CRAC channel regulator 2B; CRACR2B; EF-hand calcium-binding domain-containing protein 4A; EFC4A_HUMAN; Efcab4a.
Research Area	Cell biology  Signal transduction  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	45kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EFCAB4A: 151-250/399
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	EF-CAB4A is a 399 amino acid protein belonging to the EFCAB4 family. Containing two EF-hand domains, EF-CAB4A may be involved in store-operated Ca2+ entry (SOCE). EF-CAB4A exists as three alternatively spliced isoforms, and is encoded by a gene mapping to human chromosome 11p15.5. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11. Function: Plays a role in store-operated Ca(2+) entry (SOCE). Similarity: Belongs to the EFCAB4 family. Contains 2 EF-hand domains. SWISS: Q8N4Y2 Gene ID: 283229 Database links: Entrez Gene: 283229 Human Entrez Gene: 213573 Mouse Entrez Gene: 309112 Rat Omim: 614177 Human SwissProt: Q8N4Y2 Human SwissProt: Q80ZJ8 Mouse SwissProt: B0BNK9 Rat Unigene: 660936 Human Unigene: 386851 Mouse Unigene: 13220 Rat

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