Product Name	DOS
Chinese Name	DOS蛋白抗体
Alias	Chromosome 19 open reading frame 26; C19orf26; DOS; Protein Dos; CBARP_HUMAN; Voltage-dependent calcium channel beta subunit-associated regulatory protein; CACN Subunit Beta Associated Regulatory Protein; Calcium Channel, Voltage-Dependent, Beta Subunit Associated Regulatory Protein; CACN Beta Subunit Associated Regulatory Protein;VGCC Beta-Anchoring And -Regulatory Protein;Downstream Of STK11;Downstream Of Stk11;CBARP.
Research Area	Tumour  Cell biology  immunology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	74kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CBARP: 501-600/705
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc Alpha receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3. The C19orf26 gene product has been provisionally designated C19orf26 pending further characterization. Function: Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. Subcellular Location: Membrane. SWISS: Q8N350 Gene ID: 255057 Database links: Entrez Gene: 255057 Human SwissProt: Q8N350 Human Unigene: 346575 Human

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