TEL: +86 571 56623320 EMAIL: [email protected]
Product Name DKK4 Chinese Name 抑制因子DKK4抗体 Alias Dickkopf 4; Dickkopf gene 4; Dickkopf homolog 4 (Xenopus laevis); Dickkopf homolog 4; Dickkopf related protein 4; Dickkopf-4; Dickkopf-related protein 4 short form; Dickkopf4; DKK 4; Dkk-4; DKK4; DKK4_HUMAN; hDkk 4; hDkk-4; hDkk4; MGC129562; MGC129563. Research Area Tumour Cell biology Neurobiology Signal transduction Stem cells Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 23kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human DKK4: 151-250/224 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in cerebellum, T-cells, esophagus and lung.
Post-translational modifications:
Appears to be not glycosylated.
Can be proteolytically processed by a furin-like protease.
Similarity:
Belongs to the dickkopf family.
SWISS:
Q9UBT3
Gene ID:
27121
Database links:Entrez Gene: 27121 Human
Entrez Gene: 234130 Mouse
GenBank: NP_055235.1 Human
Omim: 605417 Human
SwissProt: Q9UBT3 Human
SwissProt: Q8VEJ3 Mouse
Unigene: 159311 Human
Unigene: 157322 Mouse
Scan Wechat Qrcode
Scan Whatsapp Qrcode