Product Name	DEFB121
Chinese Name	防御素β-121/β-defensin 121抗体
Alias	beta 121; Beta-defensin 121; Beta-defensin 21; DB121_HUMAN; DEFB-21; DEFB121; Defensin; defensin, beta 121; defensin, beta 21; ESC42RELC.
Research Area	Cell biology  immunology  Developmental biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	6.8kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DEFB121: 16-76/76
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Beta-defensins are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, Beta-defensins are developmentally regulated. The family of Beta-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many Beta-defensins also are involved in sperm maturation and capacitation. Beta-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, Beta-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other Beta-defensins, it does not appear to be regulated by androgens. Function: Has antibacterial activity. Subcellular Location: Secreted. Similarity: Belongs to the beta-defensin family. SWISS: Q5J5C9 Gene ID: 245934 Database links: Entrez Gene: 245934 Human SwissProt: Q5J5C9 Human Unigene: 272294 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DEFB121) Polyclonal Antibody, Unconjugated (SL14251R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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