Product Name	DEF8
Chinese Name	DEF8蛋白抗体
Alias	DEF-8; Def8; Def 8; DEFI8_HUMAN; Differentially expressed in FDCP 8 homolog; FLJ20186; MGC104349.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	59kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DEF8: 151-250/512
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	DEF8 is a 512 amino acid protein that is expressed at highest levels in peripheral leukocytes. It is expressed as five isoforms as a result of alternative splicing events. The gene encoding DEF8 maps to chromosome 16, which encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, a gastrointestinal inflammatory condition that may involve the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier. Similarity: Belongs to the DEF8 family. Contains 2 phorbol-ester/DAG-type zinc fingers. SWISS: Q6ZN54 Gene ID: 54849 Database links: Entrez Gene: 54849 Human SwissProt: Q6ZN54 Human Unigene: 62771 Human

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