Product Name	DDHD1
Chinese Name	磷脂酶DDHD1抗体
Alias	DDHD domain containing 1; DDHD domain containing protein 1; KIAA1705; PA-PLA1; PAPLA1; Phosphatidic acid-preferring phospholipase A1 homolog; Phospholipase DDHD1; Spastic paraplegia 28 (autosomal recessive); SPG28.
Research Area	Cell biology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	100kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DDHD1: 751-850/900
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Phosphatidic acid is released following cell activation and functions as a second messenger in several signaling pathways. DDHD1 is a lipase that catalyzes degradation of phosphatidic acid and attenuates cell activation. Function: Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity. Subunit: Forms homooligomers and, to a much smaller extent, heterooligomers with DDHD2. Subcellular Location: Cytoplasmic Tissue Specificity: Highly expressed in testis. Also expressed in brain, spleen and lung. Only expressed in cerebellum in fetal brain. DISEASE: Spastic paraplegia 28, autosomal recessive (SPG28) [MIM:609340]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Some SPG28 patients also have distal sensory impairment. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the PA-PLA1 family. Contains 1 DDHD domain. SWISS: Q8NEL9 Gene ID: 80821 Database links: Entrez Gene: 80821 Human Entrez Gene: 114874 Mouse Entrez Gene: 305816 Rat Omim: 614603 Human SwissProt: Q8NEL9 Human SwissProt: Q80YA3 Mouse Unigene: 125525 Human Unigene: 121918 Mouse Unigene: 163271 Rat

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