Product Name	CYP4F3
Chinese Name	细胞色素P450 F3抗体
Alias	CP4F3_HUMAN; CPF3; CYP4F; Cyp4f3; CYPIVF3; Cytochrome P450 4F3; Cytochrome P450 LTB omega; Cytochrome P450, family 4, subfamily F, polypeptide 3; Cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase); Cytochrome P450, subfamily IVF, polypeptide 3; Cytochrome P450-LTB-omega; Leukotriene B(4) 20 monooxygenase; Leukotriene B(4) omega hydroxylase; leukotriene B4 omega hydroxylase; Leukotriene-B(4) 20-monooxygenase 2; Leukotriene-B(4) omega-hydroxylase 2; leukotriene-B4 20-monooxygenase; LTB4 omega-hydroxylase; LTB4H.
literatures	Specific References  (1)     |     SL14160R has been referenced in 1 publications. [IF=5.738] Jie Wen. et al. OIT3 serves as a novel biomarker of hepatocellular carcinoma by mediating ferroptosis via regulating the arachidonic acid metabolism.. FRONT ONCOL. 2022 Sep;12:977348-977348  WB ;  Human.   PubMed:36132142
Research Area	Cardiovascular  Cell biology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	60kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CYP4F3: 51-150/520
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes. Subcellular Location: Endoplasmic reticulum membrane. Microsome membrane. Tissue Specificity: Expressed in the polymorphonuclear leukocytes as well as leukocytes. Similarity: Belongs to the cytochrome P450 family. SWISS: Q08477 Gene ID: 4051 Database links: Entrez Gene: 4051 Human Omim: 601270 Human SwissProt: Q08477 Human Unigene: 106242 Human

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