Product Name	CYLC2
Chinese Name	CYLC2蛋白抗体
Alias	CYL2; CYLC 2; Cylicin 2; Cylicin basic protein of sperm head cytoskeleton 2; Cylicin II; Cylicin2; Cylicin-2; MGC129591; Multiple band polypeptide II; CYLC2_HUMAN.
Research Area	Cell biology  Developmental biology  Stem cells  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	39kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CYLC2: 21-120/348
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cylicin-2 is a 348 amino acid protein encoded by the human gene CYLC2. Cylicin-1 is a type of a cytoskeletal protein which contains numerous Lys-Lys-Asp tripeptides accumulated in nine central repetitive units predicted to form a-helices. Cylicin-2, present in cow and human sperm heads, has the same prominent molecular characteristics as Cylicin-1, including a high content of charged amino acids, the abundance of Lys-Lys-Asp tripeptides and repetitive units of presumably a-helical configuration. Cylicin-2 is found in the acrosomal region of round spermatids and in the post-acrosomal region of late spermatids and spermatozoa, in agreement with the localization of Cylicin-1. Cylicin-2 is a novel Actin-binding protein, which probably plays a role in the Actin-related events that occur during spermiogenesis and the early events of fertilization. Function: CYCL2 (Cylicin II) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head and may be involved in spermatid differentiation. Subcellular Location: Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure. Tissue Specificity: Testis. SWISS: Q14093 Gene ID: 1539 Database links: Entrez Gene: 1539 Human SwissProt: Q14093 Human

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