Product Name	CRSP8
Chinese Name	转录激活蛋白CRSP8抗体
Alias	Cofactor required for Sp1 transcriptional activation subunit 8 (34kD); Cofactor required for Sp1 transcriptional activation subunit 8 34kDa; Cofactor required for Sp1 transcriptional activation subunit 8; CRAP 34; CRAP34; CRSP 34; CRSP 8; CRSP complex subunit 8; CRSP34; MED 27; Med27; MED27_HUMAN; Mediator complex subunit 27; Mediator of RNA polymerase II transcription subunit 27; MGC11274; P37 TRAP/SMCC/PC2 subunit; Transcriptional coactivator CRSP34; TRAP 37; TRAP37.
Research Area	Cell biology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	35kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CRSP8: 101-200/311
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011] Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Subcellular Location: Nucleus. Similarity: Belongs to the Mediator complex subunit 27 family. SWISS: Q6P2C8 Gene ID: 9442 Database links: Entrez Gene: 9442 Human Entrez Gene: 525389 Cow Entrez Gene: 68975 Mouse Entrez Gene: 414430 Pig Entrez Gene: 296612 Rat Omim: 605044 Human SwissProt: Q2TBN7 Cow SwissProt: Q6P2C8 Human SwissProt: Q9DB40 Mouse SwissProt: Q6Q7J5 Pig Unigene: 374262 Human Unigene: 330109 Mouse Unigene: 105472 Rat
Product Picture	Sample: Tongue (Mouse) Lysate at 40 ug Primary: Anti-CRSP8 (SL14069R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kD Observed band size: 35 kD

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