Product Name	Chemokine Receptor D6
Chinese Name	Chemokine受体D6抗体
Alias	C C chemokine receptor D6; C-C chemokine receptor D6; CC chemokine binding receptor JAB61; CC chemokine receptor D6; CCBP 2; CCBP2; ACKR2_HUMAN; CCR 10; CCR 9; CCR10; CCR9; Chemokine (C C motif) receptor 9; Chemokine (C C) receptor 9; Chemokine binding protein 2; Chemokine binding protein D6; Chemokine C C motif receptor 9; Chemokine C C receptor 9; Chemokine CC motif receptor 9; Chemokine CC receptor 9; Chemokine receptor 9; Chemokine receptor CCR 10; Chemokine receptor CCR 9; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine receptor CCR10; Chemokine receptor CCR9; Chemokine receptor D6; Chemokine-binding protein 2; Chemokine-binding protein D6; CMKBR 9; CMKBR9; D6; hD6; MGC126678; MGC138250.
Research Area	Cell biology  Signal transduction  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Chemokine Receptor D6: 101-200/384
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Chemokine Receptor D6 is a member of the C-C (β chemokine) G protein-coupled receptor family. This family is characterized by a pair of adjacent cysteine residues. C-C chemokine receptor family members also include CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7, CKR-8, CKR-9, CKR-10, CCXCKR, Bonzo, BOB (brother of Bonzo) and Duffy blood group antigen. Each of these receptors are G protein-coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to sites of inflammation. Chemokine Receptor D6 acts as a receptor for various C-C type chemokines, including SCYA2/MCP-1, SCY3/MIP-1-α, SCYA5/RANTES and SCYA7/MCP-3. It is expressed primarily in placental tissues and fetal liver, but is also detected in lymphatic endothelial cells, lymph nodes and mucosa of the small and large intestines. Function: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Subcellular Location: Cell membrane. Tissue Specificity: Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node. Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: O00590 Gene ID: 1238 Database links: Entrez Gene: 1238 Human Omim: 602648 Human SwissProt: O00590 Human Unigene: 146346 Human

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