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Product Name CHD6 Chinese Name ATP依赖的解旋酶CHD6抗体 Alias ATP dependent helicase CHD6; ATP-dependent helicase CHD6; CHD-6; CHD5; CHD6; CHD6_HUMAN; chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6; KIAA1335; Radiation induced gene B protein; Radiation-induced gene B protein; RIGB; RP4-620E11.2. Research Area Cell biology Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 305kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CHD6: 301-400/2715 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail CHD6 is a 2,715 amino acid protein encoded by the human gene CHD6. CHD6 belongs to the Snf2/Rad54 helicase family and contains two chromodomains, one ATP-binding helicase domain and one C-terminal helicase domain. The CHD family of proteins are ATP-dependent chromatin remodeling enzymes which combine chromodomains with SWI2/Snf2 ATPase/helicase motifs and DNA-binding capability. Chromodomains are protein regions of about 40-50 amino acid residues found in proteins associated with chromatin remodeling and manipulation. The domain is highly conserved among both plants and animals and is found in a large variety of proteins from many genomes.
Function:
Probable transcription regulator.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity:
Belongs to the SNF2/RAD54 helicase family.
Contains 2 chromo domains.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
SWISS:
Q8TD26
Gene ID:
84181
Database links:Entrez Gene: 84181 Human
SwissProt: Q8TD26 Human
Unigene: 371979 Human
Unigene: 644112 Human
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