Product Name	CHAD
Chinese Name	富含亮氨酸软骨蛋白抗体
Alias	Cartilage leucine rich protein; Cartilage leucine-rich protein; Chad; CHAD_HUMAN; Chondroadherin; Chondroadherin proteoglycan; SLRR4A.
Research Area	Cell biology  Signal transduction  Cell adhesion molecule  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	38kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CHAD: 281-359/359
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	CHAD is implicated in the adhesion of fibroblasts, osteoblasts and chondrocytes, which is mediated by interactions with Integrin α2/β1. Existing primarily in monomeric form, CHAD is a secreted protein that localizes to the extracellular matrix and belongs to the small leucine-rich proteoglycan (SLRP) family and class IV subfamily. CHADL (Chondroadherin-like protein) is a 762 amino acid protein containing 21 LRR (leucine-rich) repeats, which promote protein-ligand interactions. Chondroadherin, a closely related protein, promotes attachment of chrondocytes, osteoblasts and fibroblasts and also plays an important role in the regulation of chrodrocyte proliferation and growth. CHADL is a secreted protein that is located in the extracellular space. There are two isoforms of CHADL that exist as a result of alternative splicing events. Function: Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation. Subcellular Location: Secreted; extracellular space; extracellular matrix. Tissue Specificity: Present in chondrocytes at all ages. Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily. Contains 9 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. SWISS: O15335 Gene ID: 1101 Database links: Entrez Gene: 1101 Human Entrez Gene: 281069 Cow Entrez Gene: 609296 Dog Entrez Gene: 12643 Mouse Entrez Gene: 29195 Rat Omim: 602178 Human SwissProt: Q27972 Cow SwissProt: O15335 Human SwissProt: O55226 Mouse SwissProt: O70210 Rat Unigene: 97220 Human Unigene: 440523 Mouse Unigene: 9899 Rat

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