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Product Name CGREF1 Chinese Name 细胞生长调节蛋白CGREF1抗体 Alias Cell growth regulator with EF hand domain 1; Cell growth regulator with EF hand domain protein 1; Cell growth regulatory gene 11; Cell growth regulatory gene 11 protein; CGR 11; CGR11; CGRE1_HUMAN; CGREF 1; CGREF1; Hydrophobestin. Research Area Cell biology Cyclin Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 30kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CGREF1: 201-300/301 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail CGREF1 (cell growth regulator with EF-hand domain 1), also known as CGR11, is a 301 amino acid secreted protein that contains two highly conserved calcium binding EF-hand domains, which are required for mediating cell-cell adhesion. Induced by p53, CGREF1 is able to inhibit cell growth in various cell lines. CGREF1 is encoded by a gene located on human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alstrom syndrome, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.
Function:
Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.
Subunit:
Secreted (By similarity).
Similarity:
Contains 2 EF-hand domains.
SWISS:
Q99674
Gene ID:
10669
Database links:Entrez Gene: 10669 Human
Omim: 606137 Human
SwissProt: Q99674 Human
Unigene: 159525 Human
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