Product Name	HSP105
Chinese Name	热休克蛋白105抗体
Alias	Antigen NY CO 25; Antigen NY-CO-25; heat shock 105kDa protein; heat shock 105kDa/110kDa protein 1; heat shock 110kDa protein; HS105_HUMAN; Heat shock 105kD alpha; Heat shock 105kD; Heat shock 105kD beta; Heat shock 105kDa protein 1; Heat shock 105kDa protein; Heat shock 105kDa/110kDa protein 1; Heat shock 110kDa protein; Heat shock protein 105 kDa; HSP105; HSP105A; HSP105B; HSP110; HSPH 1; HSPH1; KIAA0201; NY CO 25; Antigen NY CO 25; DKFZp686M05240.
Research Area	immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	97kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HSP105: 201-350/858
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Heat Shock Proteins are ubiquitously expressed in all organisms. They are induced when a cell undergoes various types of environmental stresses like heat, cold and oxygen deprivation. They are characterized by their role as molecular chaperones. Heat shock protein (HSP) 105 exists as two isoforms; alpha and beta which belong to the HSP105/HSP110 protein family. HSP105 acts as both a chaperone to prevent thermal aggregation of proteins and as a regulator of mammalian cells. The HSP105 isoforms are found in the cytoplasm but not in the nucleoli under non-stressed and stressed conditions. Function: Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). Subunit: Interacts with HSPA8/HSC70. Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. Post-translational modifications: Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. Similarity: Belongs to the heat shock protein 70 family. SWISS: Q92598 Gene ID: 10808 Database links: Entrez Gene: 10808 Human Entrez Gene: 15505 Mouse Entrez Gene: 288444 Rat Omim: 610703 Human SwissProt: Q92598 Human SwissProt: Q61699 Mouse SwissProt: Q66HA8 Rat Unigene: 36927 Human Unigene: 270681 Mouse Unigene: 37805 Rat
Product Picture	Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-HSP105 Polyclonal Antibody, Unconjugated(SL1387R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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