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Product Name CGBP Chinese Name CpGBinding protein抗体 Alias 2410002I16Rik; 5830420C16Rik; AI426635; CFP 1; CFP1; CpG binding protein; CpG-binding protein; CXXC 1; CXXC finger 1; CXXC finger 1 PHD domain; CXXC finger protein 1; CXXC type zinc finger protein 1; CXXC-type zinc finger protein 1; CXXC1; CXXC1_HUMAN; DNA binding protein with PHD finger and CXXC domain; hCGBP; HsT2645; PCCX 1; PCCX1; PHD finger and CXXC domain containing protein 1; PHD finger and CXXC domain-containing protein 1; PHF 18; PHF18; Protein containing CXXC domain 1; SPP 1; SPP1; ZCGPC 1; ZCGPC1; Zinc finger, CpG binding type containing 1. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 56kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CGBP: 401-500/656 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001 [PubMed 11604496]).[supplied by OMIM, Mar 2008]
Function:
Transcriptional activator that exhibits a unique DNA binding specificity for [AC]CpG[AC] unmethylated CpG motifs.
Subcellular Location:
Nucleus speckle. Associated with euchromatin. During mitosis, excluded from condensed chromosomes.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
May be regulated by proteolysis.
Similarity:
Contains 1 CXXC-type zinc finger.
Contains 1 PHD-type zinc finger.
SWISS:
Q9P0U4
Gene ID:
30827
Database links:Entrez Gene: 30827 Human
Entrez Gene: 74322 Mouse
Omim: 609150 Human
SwissProt: Q9P0U4 Human
SwissProt: Q9CWW7 Mouse
Unigene: 180933 Human
Unigene: 17537 Mouse
Unigene: 86349 Rat
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