Product Name	Cezanne
Chinese Name	Cezanne蛋白抗体
Alias	Cellular zinc finger anti NF kappa B protein; Cellular zinc finger anti-NF-kappa-B protein; CEZANNE; HGNC:16683; OTU domain containing protein 7B; OTU domain containing protein 7B; OTU domain-containing protein 7B; OTU7B_HUMAN; OTUD7B; ZA20D1; Zinc finger A20 domain containing protein 1; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne.
Research Area	Cell biology  Signal transduction  Kinases and Phosphatases  Epigenetics  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	92kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Cezanne: 451-550/843
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	OTUD7B (OTU domain-containing protein 7B), also known as ZA20D1 or Cezanne, is an 843 amino acid protein that localizes to both the nucleus and the cytoplasm. Expressed in a variety of tissues, including liver, kidney, heart and immature B-cells, OTUD7B functions to hydrolyze branched and linear forms of polyubiquitin, specifically deubiquinating Lys-48- and Lys-63-linked polyubiquitin chains. Via its ability to deubiquinate target proteins, OTUD7B regulates the inflammatory response within the cell and may play a role in cell survival. More specifically, OTUD7B forms a negative feedback loop in pro-inflammatory signaling, thereby suppressing NFⅹB activity and helping to resolve inflammatory responses. OTUD7B contains one C-terminal A20-type zinc finger, one OTU domain and one N-terminal TRAF-binding domain through which it conveys its deubiquitinating activity. Function: Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin. Negative regulator of nuclear factor NF-kappa-B. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. Similarity: Belongs to the peptidase C64 family. Contains 1 A20-type zinc finger. Contains 1 OTU domain. SWISS: Q5XG92 Gene ID: 56957 Database links: Entrez Gene: 56957 Human Entrez Gene: 229603 Mouse Entrez Gene: 310677 Rat Omim: 611748 Human SwissProt: Q6GQQ9 Human Unigene: 98322 Human
Product Picture	Tissue/cell: Rat testis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Cezanne Polyclonal Antibody, Unconjugated(SL13872R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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