Product Name	CEP95
Chinese Name	中心体蛋白95抗体
Alias	CCDC45; Centrosomal protein 95kDa; Centrosomal protein of 95 kDa; Cep95; CEP95_HUMAN; Coiled coil domain containing 45; Coiled-coil domain-containing protein 45.
Research Area	Tumour  Cell biology  Cell differentiation  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	95kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CEP95: 751-821/821
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC45 (coiled-coil domain containing 45) is a 821 amino acid protein encoded by a gene that maps to human chromosome 17q23.3. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Subcellular Location: Cytoplasm; cytoskeleton; centrosome. Cytoplasm ; cytoskeleton; spindle pole. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. SWISS: Q96GE4 Gene ID: 90799 Database links: Entrez Gene: 90799 Human Entrez Gene: 320162 Mouse Entrez Gene: 287766 Rat SwissProt: Q96GE4 Human SwissProt: Q8BVV7 Mouse SwissProt: Q5XI03 Rat Unigene: 569713 Human
Product Picture	Sample: MCF-7 (Human) Cell Lysate at 40 ug Lovo (Human) Cell Lysate at 40 ug Primary: Anti-CEP95(SL13865R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 95kD Observed band size: 95kD

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