Product Name	CENTG3
Chinese Name	CENTG3蛋白抗体
Alias	AGAP-3; Agap3; AGAP3_HUMAN; ANK repeat and PH domain-containing protein 3; Arf GAP with GTPase, ANK repeat and PH domain containing protein 3; Arf-GAP with GTPase; ArfGAP with GTPase domain, ankyrin repeat and PH domain; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; centaurin gamma 3; Centaurin-gamma-3; CENTG3; Cnt-g3; CRAG; CRAM-associated GTPase; CRMP (collapsin response mediator protein) associated; FLJ16146; FLJ34452; MR1-interacting protein; MRIP-1; MRIP1; OTTHUMP00000213333; OTTHUMP00000213334; OTTHUMP00000213335; OTTHUMP00000213336.
Research Area	Cell biology  Signal transduction  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	95kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CENTG3: 51-150/875
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP OTTHUMP00000213337; domain, five PH domains, one Ras-associating domain, one Rho-GAP domain and one SAM (sterile a motif) domain. Function: GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. Subcellular Location: Cytoplasm. In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies. Tissue Specificity: Widely expressed. Similarity: Belongs to the centaurin gamma-like family. Contains 3 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain. SWISS: Q96P47 Gene ID: 116988 Database links: Entrez Gene: 116988 Human Entrez Gene: 213990 Mouse Entrez Gene: 362300 Rat SwissProt: Q96P47 Human SwissProt: Q8VHH5 Mouse Unigene: 647075 Human Unigene: 250703 Mouse

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