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Product Name CENPI Chinese Name 着丝粒蛋白I抗体 Alias CENP I; CENPI_HUMAN; centromere protein I; Follicle simulating hormone primary response protein; FSH primary response 1; FSH primary response protein 1; FSH primary response, rat, homolog of, 1; FSHP1; FSHPRH1; interphase centromere complex protein 19; Leucine rich primary response gene 1; Leucine rich primary response protein 1; LRPR1; Mis6. Research Area Cell biology Developmental biology Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 87kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CENPI: 201-300/756 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis. [provided by RefSeq, Jul 2008]
Function:
CENPI is a constitutive protein of the knetochore that shares limited similarity with Mis6 of S. pombe. The kinetochore is a macromolecular complex located at the centromere of chromosomes and provides essential functions for chromosome segregration. CENPI is required for the localization of CENPF and the checkpoint proteins MAD1 and MAD2 to the kinetochore.
Subcellular Location:
Cytoplasmic and Nuclear
Post-translational modifications:
Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation.
Similarity:
Belongs to the mis6 family.
SWISS:
Q92674
Gene ID:
2491
Database links:Entrez Gene: 2491 Human
Omim: 300065 Human
SwissProt: Q92674 Human
Unigene: 348920 Human
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