Product Name	CTNNA3
Chinese Name	钙粘蛋白相关蛋白CTNNA3抗体
Alias	4930429L08Rik; 4933408A16; Alpha catenin like protein; Alpha T catenin; Alpha T-catenin; Cadherin associated protein; Cadherin-associated protein; Catenin alpha 3; Catenin alpha-3; Catna3; CTNA3_HUMAN; CTNNA3; MGC26194; MGC75041; OTTHUMP00000019684; OTTMUSP00000028119; OTTMUSP00000028120; RP11-433J16.1; VR22.  α T-catenin
Research Area	Cell biology  Signal transduction  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	100kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CTNNA3: 131-230/895
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The catenins are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantally expressed in cardiomyocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer's disease (LOAD) as well as to dilated cardiomyopathy. Function: May be involved in formation of stretch-resistant cell-cell adhesion complexes. Subcellular Location: Cytoplasm; cytoskeleton. Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. Tissue Specificity: Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle. Similarity: Belongs to the vinculin/alpha-catenin family. SWISS: Q9UI47 Gene ID: 29119 Database links: Entrez Gene: 29110 Human Entrez Gene: 29119 Human Entrez Gene: 216033 Mouse Entrez Gene: 361839 Rat Omim: 607667 Human SwissProt: Q9UHD2 Human SwissProt: Q9UI47 Human SwissProt: Q65CL1 Mouse Unigene: 660362 Human Unigene: 444692 Mouse Unigene: 223553 Rat

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