Product Name	Lipocalin 2/NGAL
Chinese Name	脂质运载蛋白抗体
Alias	Lipocalin 2; Neutrophil Gelatinase associated Lipocalin; 25 kDa alpha 2 microglobulin related subunit of MMP9; Alpha 2 microglobulin related protein; HGNC:6526; HNL; Lcn 2; LCN-2; Lcn2; Neutrophil gelatinase associated lipocalin precursor; NGAL; Oncogene 24p3; P25; SV40 induced 24P3 protein. 24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Migration stimulating factor inhibitor; MSFI; Neutrophil gelatinase associated lipocalin precursor; Neutrophil gelatinase-associated lipocalin; NGAL_HUMAN; Oncogenic lipocalin 24p3; Siderocalin; siderocalin LCN2; SV40 induced 24P3 protein.
literatures	Specific References  (4)     |     SL1373R has been referenced in 4 publications. [IF=6.16] Xing, Changhong, et al. "Neuronal Production of Lipocalin-2 as a Help-Me Signal for Glial Activation." Stroke (2014): STROKEAHA-114.  IHC-P ;  Human.   PubMed:24916903 [IF=4.041] Chen, Yi-Hung. et al. Electroacupuncture improves repeated social defeat stress-elicited social avoidance and anxiety-like behaviors by reducing Lipocalin-2 in the hippocampus. Mol Brain. 2021 Dec;14(1):1-25  IF ;  Mouse.   PubMed:10.1186/s13041-021-00860-0 [IF=3.934] Wang Z et al. Fetal Bisphenol-A Induced Changes in Murine Behavior and Brain Gene Expression Persisted in Adult-aged OffspringEndocrinology.2020 Dec 1;161(12):bqaa164.  IHC ;  Mouse.   PubMed:32926169 [IF=3.647] Lin D et al. Aldehyde dehydrogenase 2 regulates autophagy via the Akt-mTOR pathway to mitigate renal ischemia-reperfusion injury in hypothermic machine perfusion. Life Sci . 2020 Jul 15;253:117705.  IHC,WB ;  mouse.   PubMed:32334008
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  Apoptosis  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Lipocalin 2: 101-198/198
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Lipocalin 2 is a member of the lipocalin family which encompass more than 25 members (including proteins like retinol binding protein, a1 microglobulin, b lactoglobulin, apolipoprotein D and odorant binding protein). The members of the lipocalin family are characterized by their ability to bind small lipophilic substances in their hydrophobic core, and thereby serve as transporters of substances. Function: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Subunit: Homodimer; disulfide-linked. Heterodimer; disulfide-linked with MMP9. Subcellular Location: Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized. Tissue Specificity: Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. Similarity: Belongs to the calycin superfamily. Lipocalin family. SWISS: P80188 Gene ID: 3934 Database links: Entrez Gene: 3934 Human Entrez Gene: 16819 Mouse Entrez Gene: 170496 Rat Omim: 600181 Human SwissProt: P80188 Human SwissProt: P11672 Mouse SwissProt: P30152 Rat Unigene: 204238 Human Unigene: 9537 Mouse Unigene: 11303 Rat NGAL在胚胎发育、Cell differentiation、Apoptosis、细胞Signal transduction、脂质代谢及Tumour的发生发展以及参与炎症免疫反应等多种生命活动过程中发挥着作用，尤其是近年来在消化系统Tumour的研究中，受到了重视。
Product Picture	Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-NGAL Polyclonal Antibody, Unconjugated(SL1373R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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