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Product Name FAT4 Chinese Name 钙粘蛋白14抗体 Alias CDHF14; FAT4_HUMAN; Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FATJ; hFat4; Nbla00548; Protocadherin Fat 4. Research Area Tumour Cell biology Signal transduction Cell adhesion molecule Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 538kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CDHF14: 4351-4450/4981 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]
Function:
May function in the regulation of planar cell polarity. Cadherins are cell-cell interaction molecules.
Subcellular Location:
Membrane. In the kidney, localizes to primary cilia.
Tissue Specificity:
Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer.
Similarity:
Contains 34 cadherin domains.
Contains 6 EGF-like domains.
Contains 2 laminin G-like domains.
SWISS:
Q6V0I7
Gene ID:
79633
Database links:Entrez Gene: 79633 Human
SwissProt: Q6V0I7 Human
Unigene: 563205 Human
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