Product Name	EPB41L5
Chinese Name	红The cell membrane蛋白条带EPB41L5抗体
Alias	Band 4.1-like protein 5; BE37; E41L5_HUMAN; Epb41l5; erythrocyte membrane protein band 4.1 like 5; KIAA1548.
Research Area	Cell biology  Cell Surface Molecule  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	82kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EPB41L5: 51-150/733
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	FERM domains are roughly 150 amino acids in length and are found in a number of cytoskeletal-associated proteins such as Ezrin, Radixin, Moesin and 4.1 (erythrocyte membrane protein band 4.1), where they provide a link between cytoskeletal signals and membrane dynamics. EPB41L5 (erythrocyte membrane protein band 4.1 like 5), also known as BE37 or YMO1, is a 733 amino acid cytoplasmic protein that contains one FERM domain, which it uses to bind CRB1 (crumbs homolog 1). EPB41L5 is a homolog of zebrafish 'mosaic eyes' (moe), and is widely expressed but found at highest levels in ovary, kidney and brain, and is known to colocalize with β-catenin. EPB41L5 may participate in tight junction positioning during the establishment of epithelial cell polarity, and exists as four alternatively spliced isoforms that are encoded by a gene located on human chromosome 2q14.2. Function: May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells. Subcellular Location: Cytoplasm. Cell junction > adherens junction. Associated with the plasma membrane. Colocalizes with CTNNB1, an adherens junction marker. Similarity: Contains 1 FERM domain. SWISS: Q9HCM4 Gene ID: 57669 Database links: Entrez Gene: 57669 Human Omim: 611730 Human SwissProt: Q9HCM4 Human Unigene: 369232 Human

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