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Product Name HoxC13 Chinese Name 同源盒蛋白HOX13抗体 Alias ECTD9; Homeo box 3G; Homeo box C13; homeobox C13; Homeobox protein Hox 3G; Homeobox protein Hox-C13; Hox-3G; HOX3; HOX3G; HOXC13; HXC13; NUP98. literatures Specific References (3) | SL13599R has been referenced in 3 publications.[IF=2.752] Yanyu He. et al. Altered Hypoxia-Induced and Heat Shock Protein Immunostaining in Secondary Hair Follicles Associated with Changes in Altitude and Temperature in Tibetan Cashmere Goats. Animals-Basel. 2021 Oct;11(10):2798 IF,IHC ; goat.[IF=1.343] He et al. Determination of Secondary Follicle Characteristics, Density, Activity, and Hoxc13 Expression Pattern of Hexi Cashmere Goats Breed. (2015) Anat.Rec.(Hoboken). 298:1796-803 IHC-P ; Goat.[IF=1.34] He, Yanyu, et al. "Determination of secondary follicle characteristics, density, activity and Hoxc13 expression pattern of Hexi cashmere goats breed." The Anatomical Record (2015). IHC-P ; Goat.Research Area Cell biology Stem cells transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 35kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HoxC13: 231-330/330 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The Hox proteins are a family of transcription factors that play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. Hox proteins are involved in controlling axial patterning, leukemias and hereditary malformations. HoxC13 (homeobox C13), also known as HOX3 or HOX3G, is a 330 amino acid protein that contains one homeobox DNA-binding domain and is a member of the Abd-B homeobox family. Localized to the nucleus, HoxC13 functions as a sequence-specific transcription factor that, in conjunction with a variety of other proteins, provides cells with positional identities on their anterior-posterior axis. Via its ability to modify features of the anterior-posterior body axis, HoxC13 is thought to play a role in the development of nails, hair and filiform papilla.
Function:
HOXC13 is a member of a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms and provide cells with specific positional identities on the anterior-posterior axis. HOXC13 is a sequence-specific transcription factor that may play a role in the development of hair, nail, and filiform papilla.
Subcellular Location:
Nuclear
Similarity:
Belongs to the Abd-B homeobox family.
Contains 1 homeobox DNA-binding domain.
SWISS:
P31276
Gene ID:
3229
Database links:Entrez Gene: 3229 Human
Entrez Gene: 15422 Mouse
Omim: 142976 Human
SwissProt: P31276 Human
SwissProt: P50207 Mouse
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