Product Name	ZBTB46
Chinese Name	Zinc finger protein340抗体
Alias	BTB/POZ domain containing protein 4; BTBD4; RINZF; Zinc finger and BTB domain containing 46; Zinc finger and BTB domain containing protein 46; Zinc finger protein 340; ZNF340; ZBT46_HUMAN.
Research Area	Cell biology  transcriptional regulatory factor  Zinc finger protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	64kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ZBTB46: 401-500/589
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	BTBD4 is a 589 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD4 may play a role in transcription regulation. Function: ZBTB46 may be involved in transcriptional regulation. It contains one BTB (POZ) domain and two C2H2 type zinc fingers. Tissue Specificity: Nucleus (Potential). Post-translational modifications: Sumoylated. Desumoylation by PPPDE2 reverses transcriptional repression activity (By similarity). Similarity: Contains 1 BTB (POZ) domain. Contains 2 C2H2-type zinc fingers. SWISS: Q86UZ6 Gene ID: 140685 Database links: Entrez Gene: 140685 Human Entrez Gene: 72147 Mouse SwissProt: Q86UZ6 Human SwissProt: Q8BID6 Mouse Unigene: 585028 Human
Product Picture	Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti-ZBTB46 (SL13579R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 64 kD Observed band size: 64 kD

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