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Product Name GGT2 heavy chain Chinese Name γ-谷氨酰转肽酶2重链抗体 Alias GGT 2; GGT-2; Gamma-glutamyltranspeptidase 2 heavy chain; Gamma glutamyltranspeptidase 2; gamma-glutamyltranspeptidase; GGT2_HUMAN; Glutathione hydrolase 2; Gamma-glutamyltranspeptidase 2. Research Area Cell biology Signal transduction Stem cells Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 42kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Gamma-glutamyltranspeptidase 2 heavy chain: 101-200/569 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail GGT acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage, and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts leukotriene C4 to leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and in human tissues, there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes.
Function:
Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Tissue Specificity:
Highly expressed in fetal and adult kidney and liver.
Similarity:
Belongs to the gamma-glutamyltransferase family.
SWISS:
P36268
Gene ID:
728441
Database links:Entrez Gene: 728441 Human
Omim: 137181 Human
SwissProt: P36268 Human
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