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Product Name Gcn1l1 Chinese Name 广泛控制氨基酸合成1样蛋白1抗体 Alias GCN1; GCN1 (general control of amino acid synthesis yeast homolog) like; GCN1 (general control of amino acid synthesis 1 yeast) like 1; GCN1 general control of amino acid synthesis 1 like 1; GCN1 general control of amino acid synthesis 1 like 1 (yeast); GCN1 like protein 1; GCN1L; HsGCN1; GCN1L_HUMAN. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 293kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Gcn1l1: 751-850/2671 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail GCN1L1 is a 2,671 amino acid protein that is ubiquitously expressed and belongs to the GCN1 family. Functioning as a translation activator, GCN1L1 interacts with IMPACT to regulproteinate GCN2 kinase activity. GCN1L1 contains 24 HEAT repeats and is encoded by a gene that maps to human chromosome 12q24.23. Chromosome 12 encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.
Function:
Gcn1l1 acts as a translation activator which mediates translational control and performs an EF3-related function on the ribosome by regulating GCN2 protein kinase (EIF2AK1-4) activity.
Subunit:
Interacts with IMPACT; prevents the interaction with GCN2 protein kinase (EIF2AK1-4) (By similarity).
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the GCN1 family.
Contains 24 HEAT repeats.
SWISS:
Q92616
Gene ID:
10985
Database links:Entrez Gene: 10985 Human
Entrez Gene: 231659 Mouse
Omim: 605614 Human
SwissProt: Q92616 Human
SwissProt: E9PVA8 Mouse
SwissProt: Q8BIX2 Mouse
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