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Product Name GSDMB Chinese Name GSDML蛋白抗体 Alias Gasdermin-B; Gasdermin-like protein; Gasdermin-B, N-terminal; GSDMB-NT; p30; Gasdermin-B, C-terminal; GSDMB-CT; p16; GSDML; PP4052; PRO2521; GSDMB_HUMAN; Research Area Tumour Apoptosis Cyclin Binding protein Extracellular matrix Immunogen Species Rabbit Clonality Polyclonal React Species Human, Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 47kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GSDMB: 171-270/411 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail GSDML is a member of the GSDMDC (gasdermin-domain containing) family of proteins. Members of the GSDMDC family are involved in a wide variety of cellular processes, including cell-cycle control, extracellular matrix production, differentiation and apoptosis, and have been associated with the development and progression of cancer. GSDML is a widely expressed protein found in both cancerous and non-cancerous tissues localizing to the cytoplasm and in secretory vesicles. The gene encoding GSDML is thought to have been generated by a duplication event of the GSDM1 gene which encodes gasdermin. In addition, various isoforms exist for GSDML.
Function:
May play a role as secretory or metabolic product involved in secretory pathway. May also play a role in achieving and maintaining the final differentiation state of epithelial cells.
Subcellular Location:
Cytoplasm. Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.
Tissue Specificity:
Expressed in gastric, liver and colon cell lines, carcinomas and non-lesional tissues.
Similarity:
Belongs to the gasdermin family.
SWISS:
Q8TAX9
Gene ID:
55876
Database links:Entrez Gene: 55876 Human
Omim: 611221 Human
SwissProt: Q8TAX9 Human
Unigene: 306777 Human
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