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Product Name GAPT Chinese Name 生长因子受体结合适应蛋白抗体 Alias C5orf29; Gapt; GAPT_HUMAN; Grb2-binding adaptor transmembrane; Growth factor receptor-bound protein 2-binding adapter protein; Growth factor receptor-bound protein 2-binding adapter protein, transmembrane; Protein GAPT; transmembrane. Research Area Tumour Cell biology Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 18kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GAPT: 21-120/157 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. The C5orf29 gene product has been provisionally designated C5orf29 pending further characterization.
Function:
Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells.
Subunit:
Interacts with GRB2.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Highly expressed in spleen and PBL, detected at lower levels in thymus, and undetectable in all other tissues tested. Also expressed in various B-cell lines, monocytic cell line THP-1 and NK-like cell line YT, but not in T-cell line Jurkat or HeLa cells.
Similarity:
Belongs to the GAPT family.
SWISS:
Q8N292
Gene ID:
202309
Database links:Entrez Gene: 202309 Human
SwissProt: Q8N292 Human
Unigene: 547697 Human
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