Product Name	FUNDC1
Chinese Name	X三体综合症相关蛋白FUNDC1抗体
Alias	FUN14 domain containing protein 1; FUN14 domain-containing protein 1; FUND1_HUMAN.
literatures	Specific References  (1)     |     SL13227R has been referenced in 1 publications. [IF=4.011] Xu G et al. Fundc1 is necessary for proper body axis formation during embryogenesis in zebrafish. Sci Rep. 2019 Dec 11;9(1):18910.  WB ;  grass carp&Human.   PubMed:31827208
Research Area	Cell biology  immunology  Developmental biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:300-800 ELISA=1:5000-10000 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	17kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FUNDC1: 51-150/155
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	FUNDC1 is a 155 amino acid protein belonging to the FUN14 family. The gene encoding FUNDC1 maps to human chromosome Xp11.3 and mouse chromosome X A1.2. The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. Subunit: Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP. Subcellular Location: Mitochondrion outer membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy. Similarity: Belongs to the FUN14 family. SWISS: Q8IVP5 Gene ID: 139341 Database links: Entrez Gene: 139341 Human Entrez Gene: Mouse Entrez Gene: 72018 Mouse Entrez Gene: 363442 Rat Omim: 300871 Human SwissProt: Q8IVP5 Human SwissProt: Q9DB70 Mouse SwissProt: Q5BJS4 Rat
Product Picture	Sample: Lane 1: Mouse Cerebellum tissue lysates Lane 2: Mouse Heart tissue lysates Lane 3: Human 293T cell lysates Lane 4: Human MCF-7 cell lysates Lane 5: Human A549 cell lysates Primary: Anti-FUNDC1 (SL13227R) at 1/800 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 17 kDa Observed band size: 17 kDa

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