Product Name	FUBP1
Chinese Name	DNA解旋酶V抗体
Alias	FBP1; DNA helicase V; far upstream element (FUSE) binding protein 1; Far upstream element (FUSE) binding protein 4; Far upstream element binding protein 1; far upstream element binding protein; Far upstream element-binding protein 1; FBP; FUBP; Fubp1; FUBP1_HUMAN; Fubp4; FUSE binding protein 1; FUSE-binding protein 1; HDH V.
Research Area	Cell biology  Signal transduction  transcriptional regulatory factor  Cell differentiation  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	68kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FUBP1/DNA helicase V/FBP1: 551-644/644
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Activation of FUSE, the far upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP1 (FUSE-binding protein or far upstream element-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP1 functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL-60 cells, FBP1 (FBP), FBP2 and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP1 is detected in undifferentiated cells and is substantially decreased following cellular differentiation. Function: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. Subunit: Found in a complex with PUF60 and far upstream element (FUSE) DNA segment. Interacts with PUF60 and JTV1. Subcellular Location: Nucleus. Post-translational modifications: Ubiquitinated. This targets the protein for proteasome-mediated degradation. Similarity: Contains 4 KH domains. SWISS: Q96AE4 Gene ID: 8880 Database links: Entrez Gene: 8880 Human Entrez Gene: 51886 Mouse Entrez Gene: 654496 Rat Entrez Gene: 513562 Cow Omim: 603444 Human SwissProt: Q96AE4 Human SwissProt: Q91WJ8 Mouse SwissProt: Q32PX7 Rat Unigene: 567380 Human Unigene: 278922 Mouse Unigene: 177078 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (mouse intestine); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FUBP1) Polyclonal Antibody, Unconjugated (SL13224R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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