Product Name	FNIP2
Chinese Name	卵泡刺激素Binding protein2抗体
Alias	FNIP1-like protein; Fnip2; FNIP2_HUMAN; FNIPL; Folliculin-interacting protein 2; KIAA1450; MAPO1; O6-methylguanine-induced apoptosis 1 protein; OTTHUMP00000221326.
literatures	Specific References  (1)     |     SL13194R has been referenced in 1 publications. [IF=6.684] Lijin Guo. et al. Whole Transcriptome Analysis Reveals a Potential Regulatory Mechanism of LncRNA-FNIP2/miR-24-3p/FNIP2 Axis in Chicken Adipogenesis. Front Cell Dev Biol. 2021; 9: 653798  WB ;  Chicken.   PubMed:34249911
Research Area	Tumour  Cell biology  Signal transduction  Binding protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	122kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FNIP2: 1001-1114/1114
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Folliculin is a cytoplasmic protein that is suggested to be involved in the pathogenesis of a uncommon form of kidney cancer through its association with Birt-Hogg-Dube syndrome, an inherited disorder of the hair follicle. FNIP2 (folliculin interacting protein 2), also known as FNIPL or MAPO1, is a 1,114 amino acid protein that belongs to the FNIP family and is widely expressed, with highest expression in muscle, nasal mucosa, salivary gland, uvula, fat, liver and pancreas and low expression in renal cell carcinoma and normal kidney tissue. Localized to the cytoplasm, FNIP2 may participate in energy and/or nutrient sensing through the AMPK and FRAP signaling pathways. FNIP2 exists as two alternatively isoforms and forms homomultimers and heteromultimers with FNIP1. FNIP2 interacts with folliculin via its C-terminus and with AMPK alpha 1, AMPK beta 1 and AMPK gamma 1 subunits of 5'-AMP-activated protein kinase. Function: May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. Subunit: Forms homomultimers and heteromultimers with FNIP1. Interacts (via C-terminus) with FLCN (via C-terminus). Phosphorylated FLCN is preferentially bound. Interacts with PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase. Subcellular Location: Cytoplasm. Co-localizes with FLCN in the cytoplasm. Tissue Specificity: Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenty and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue. Higher levels detected in oncocytoma than in normal kidney. Post-translational modifications: Phosphorylated by AMPK. Similarity: Belongs to the FNIP family. SWISS: Q9P278 Gene ID: 57600 Database links: Entrez Gene: 57600 Human Entrez Gene: 329679 Mouse Entrez Gene: 310538 Rat Omim: 612768 Human SwissProt: Q9P278 Human SwissProt: Q80TD3 Mouse Unigene: 652441 Human Unigene: 728209 Human Unigene: 244005 Mouse
Product Picture	Sample: 293T Cell (Human) Lysate at 40 ug Primary: Anti- FNIP2 (SL13194R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 122 kD Observed band size: 122 kD

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