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Product Name FKBP25 Chinese Name 肽基脯氨酸异构酶酶FKBP25抗体 Alias FKBP 25; FKBP 3; FKBP25; FKBP3; PPIase; Rotamase; FKBP3_HUMAN. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 25kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FKBP25: 31-130/224 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail FKBP25 is a member of the immunophilin protein family. The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. They inhibit T-cell proliferation by interrupting two specific cytoplasmic signal transmission pathways. FKBP25 is localized in the nucleus and is expressed in the brain, testis, ovary, and spleen. It may influence immunoregulation and cerebellum development, as well as protein folding and trafficking in neurons. FKBP25 associates with transcriptional repressor protein YY1 and histone deaceltylases, HDAC1 and HDAC2. FKBP25 may contain several casein kinase II phosphorylation sites, which are believed to be important for cell growth regulation.
Function:
FK506 binding proteins (FKBPs) are peptidyl proline isomerase enzymes (catalyzing the interconversion of cis-> trans proline in proteins). Cytosolic FKBPs are inhibited by the immunosuppressive drugs FK506 and rapamycin, and regulate calcineurin signalling in T cells. A unique member of the FKBP family is FKBP25 (also known as FKBP3). It is localized to the nucleus, and has been shown to interact with the transcription factor YY1 and HDAC enzymes. These observations suggest that FKBP25 may play a direct role in transcriptional regulation and chromatin modifications. FKBP25 has also been shown to be down-regulated following p53 induction.
Subcellular Location:
Nuclear
Similarity:
Belongs to the FKBP-type PPIase family.
Contains 1 PPIase FKBP-type domain.
SWISS:
Q00688
Gene ID:
2287
Database links:
Entrez Gene: 2287 Human
Entrez Gene: 30795 Mouse
Entrez Gene: 100009004 Rabbit
Omim: 186947 Human
SwissProt: Q00688 Human
SwissProt: Q62446 Mouse
SwissProt: O46638 Rabbit
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