Product Name	FKBP11
Chinese Name	肽基脯氨酰顺反异构酶FKBP11抗体
Alias	19 kDa FK506 binding protein; 19 kDa FK506-binding protein; 19 kDa FKBP; FK506 binding protein 11 (19 kDa); FK506 binding protein 11; FK506-binding protein 11; FKB11_HUMAN; FKBP 19; FKBP-11; FKBP-19; Fkbp11; FKBP19; MGC54182; Peptidyl prolyl cis trans isomerase; Peptidyl-prolyl cis-trans isomerase FKBP11; PPIase; PPIase FKBP11; Rotamase.
literatures	Specific References  (1)     |     SL13176R has been referenced in 1 publications. [IF=3.828] Thokerunga Erick. et al. FKBP11 upregulation promotes proliferation and migration in hepatocellular carcinoma. CANCER BIOMARK. 2023 May;Preprint(Preprint):1-12  WB,IHC ;  Human.   PubMed:37248890
Research Area	Cell biology  Neurobiology  transcriptional regulatory factor  Binding protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	19kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FKBP11: 121-201/201
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. Immunophilins have also been implicated in protein folding and trafficking within the endoplasmic reticulum (ER). FKBP11 (FK506-binding protein 11), also known as FKBP19 or peptidyl-prolyl cis-trans isomerase FKBP11, is a 201 amino acid single-pass membrane protein belonging to the FKBP-type PPIase family, a group of proteins known to catalyze the folding of proline-containing polypeptides. Containing one PPIase FKBP-type domain, FKBP11 is expressed in secretory tissues such as pancreas, pituitary, stomach, lymph node and salivary gland, and is encoded by a gene that maps to human chromosome 12q13.12. FK506 and rapamycin are known to inhibit FKBP11’s peptidyl-prolyl isomerase activity. Function: PPIases accelerate the folding of proteins during protein synthesis. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Similarity: Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain. SWISS: Q9NYL4 Gene ID: 51303 Database links: Entrez Gene: 51303 Human Entrez Gene: 66120 Mouse Omim: 610571 Human SwissProt: Q9NYL4 Human SwissProt: Q9D1M7 Mouse Unigene: 655103 Human Unigene: 30729 Mouse

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